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Nemotron-4-340B-Instruct is an English-language chat model optimized for synthetic data generation. This large language model (LLM) is a fine-tuned version of Nemotron-4-340B-Base, designed for single and multi-turn chat use-cases with a 4,096 token context length. The base model was pre-trained on 9 trillion tokens from diverse English texts, 50+ natural languages, and 40+ coding languages. The instruct model underwent additional alignment steps: 1. Supervised Fine-tuning (SFT) 2. Direct Preference Optimization (DPO) 3. Reward-aware Preference Optimization (RPO) The alignment process used approximately 20K human-annotated samples, while 98% of the data for fine-tuning was synthetically generated. Detailed information about the synthetic data generation pipeline is available in the technical report.